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Study shows hemp compounds prevent coronavirus from entering human cells

Laboratory research is a collaboration of researchers at OHSU, Oregon State University
Study shows hemp compounds prevent coronavirus from entering human cells. Hemp growing in a field amid the dawn.

“The study’s implication is that some hemp-based consumer products have the potential to prevent as well as treat infection from the novel coronavirus,” said senior author Fikadu Tafesse, Ph.D., assistant professor of molecular microbiology and immunology in the OHSU School of Medicine. (Getty Images)

New research reveals compounds in hemp demonstrate an ability to prevent the virus that causes COVID-19 from entering human cells.

The study, published in the Journal of Natural Products, was a collaboration between scientists at Oregon Health & Science University and Oregon State University.

The laboratory study used chemical screening techniques to discover that a pair of distinct cannabinoid acids in hemp — known as cannabigerol acid, or CBGA, and cannabidiolic acid, or CBDA — bind to the SARS-CoV-2 spike protein, blocking a critical step in the process the virus uses to infect people.

Fikadu Tafesse Ph.D. (OHSU), a tall man with dark hair smiling in the Vollum courtyard at OHSU.

Fikadu Tafesse, Ph.D. (OHSU)

“This is a lab study, so it hasn’t been tested clinically,” said senior author Fikadu Tafesse, Ph.D., assistant professor of molecular microbiology and immunology in the OHSU School of Medicine. “However, the study’s implication is that some hemp-based consumer products have the potential to prevent as well as treat infection from the novel coronavirus.”

Known scientifically as Cannabis sativa, hemp is a source of fiber, food, and animal feed. Hemp extracts and compounds are also added to cosmetics, body lotions, and dietary supplements.

The study was led by Richard van Breeman, Ph.D., a researcher with Oregon State’s Global Hemp Innovation Center, College of Pharmacy, and Linus Pauling Institute.

In addition to Tafesse and van Breeman, co-authors include Ruth Muchiri of Oregon State, along with Timothy Bates, Jules Weinstein, Hans Leier, and Scotland Farley of OHSU.

For more information, see the news release from Oregon State University: https://today.oregonstate.edu/news/oregon-state-research-shows-hemp-compounds-prevent-coronavirus-entering-human-cells

 

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Doctor speaking with patient. What Are the Benefits of CBD?
Pain Anxiety and Depression Cancer-Related Symptoms Heart Health Epilepsy and Seizure Gastrointestinal Disorder Asthma Endocannabinoid System

What Are the Benefits of CBD?

More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?

By Dawn MacKeen

The CBD industry is flourishing, conservatively projected to hit $16 billion in the United States by 2025. Already, the plant extract is being added to cheeseburgers, toothpicks and breath sprays. More than 60 percent of CBD users have taken it for anxiety, according to a survey of 5,000 people, conducted by the Brightfield Group, a cannabis market research firm.Chronic pain, insomnia and depression follow behind. Kim Kardashian West, for example, turned to the product when “freaking out” over the birth of her fourth baby. The professional golfer Bubba Watson drifts off to sleep with it. And Martha Stewart’s French bulldog partakes, too.

Cannabidiol, or CBD,is the lesser-known child of the cannabis sativaplant; its more famous sibling, tetrahydrocannabinol, or THC, is the active ingredient in pot that catapults users’ “high.” With roots in Central Asia, the plant is believed to have been first used medicinally — or for rituals — around 750 B.C., though there are other estimates too.

Cannabidiol and THC are just two of the plant’s more than 100 cannabinoids. THC is psychoactive, and CBD may or may not be, which is a matter of debate. THC can increase anxiety; it is not clear what effect CBD is having, if any, in reducing it. THC can lead to addiction and cravings; CBD is being studied to help those in recovery.

Cannabis containing 0.3 percent or less of THC is hemp. Although last year’s Farm Bill legalized hemp under federal law, it also preserved the Food and Drug Administration’s oversight of products derived from cannabis.

CBD is advertised as providing relief for anxiety, depression and post-traumatic stress disorder. It is also marketed to promote sleep. Part of CBD’s popularity is that it purports to be “nonpsychoactive,” and that consumers can reap health benefits from the plant without the high (or the midnight pizza munchies).

Just as hemp seedlings are sprouting up across the United States, so is the marketing. From oils and nasal sprays to lollipops and suppositories, it seems no place is too sacred for CBD. “It’s the monster that has taken over the room,” Dr. Brad Ingram, an associate professor of pediatrics at the University of Mississippi Medical Center, said about all the wild uses for CBD now. He is leading a clinical trial into administering CBD to children and teenagers with drug-resistant epilepsy.

 

CBG is the hardest cannabinoid to produce.
Gastrointestinal Disorder Endocannabinoid System Pain Anxiety and Depression Cancer-Related Symptoms Heart Health Epilepsy and Seizure Asthma

Why CBG (Cannabigerol) Is One Of The Most Expensive Cannabinoids To Produce

As CBD continues to explode in popularity, brands are beginning to take notice. Innovative companies are already beginning to offer products centered around one of the other 100+ cannabinoids found in the plant.

One of those cannabinoids is Cannabigerol, or CBG. First discovered by researchers in the 1960’s, CBG is the precursor from which all other cannabinoids are synthesized, which is why it’s often referred to as the “mother” or “stem cell” of cannabinoids. This unique property imbues CBG with enormous therapeutic promise, making it a subject of great interest for researchers and consumers alike.

“It’s definitely gaining momentum,” says James Rowland, CEO of Steve’s Goods, a Colorado based brand that specializes in producing CBG goods. “We have personally administered CBG to thousands of people at over 50 events. It’s the most requested product on our website and we provide education to thousands of receptive people both in person and online every month.”

CBG (Cannabigerol) being made

CBG (Cannabigerol) being made PHOTOS COURTESY OF STEVE’S GOODS

The US government is also keen on learning more about CBG. In 2018 The National Center for Complementary and Integrative Health (NCCIH) announced an intent to research minor cannabinoids including CBG that could help manage pain. Today In: Lifestyle

So how exactly does CBG work?

“CBG works by interacting with the endocannabinoid system (ECS). Together, CB1 and CB2 receptors regulate neurohormones which actively affect physiological processes including mood, metabolism, pain response, and appetite,” begins Derek Du Chesne, Chief Growth Officer at EcoGen Laboratories. “When cannabinoids like CBG interact with these receptors, it activates a response and produces physiological changes.”

 

 

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