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How Hemp/CBD Changed Medicine

Hemp/CBD & Your Health/Wellness

Here at Native Roots Hemp we spend most of our time helping guests better understand the endocannabinoid system and how our organically grown Wisconsin hemp helps the body remain in a more balanced state of being.

But sometimes, others can explain it even better! The article below talks about the Endocannabinoid System and it’s profound effects on the human body.

Hemraj, Dipak. “The Discovery of the Endocannabinoid System: How It’s Changed Medicine.” Cannabis Science, Leafwell.com, April 16, 2018, leafwell.com

It has been written or said in many places, but it is something that needs to be reiterated: had cannabis not become such a maligned plant, Raphael Mechoulam and his team would be awarded the Nobel Prize for the discovery of the endocannabinoid system (ECS). In fact, there are several researchers in the field of endocannoids and phytocannabinoids who would be worthy of such a prize. Thankfully, they have at least been awarded a multitude of other prizes, so we can be assured that there is at least some sense in the world. After all, “If viagra can win the Nobel Prize, why not cannabis?” (Please watch The Scientist to get this reference.)

Endocannabinoid system; ECS; CB1 receptors; CB2 receptors

These scientists have won so many prizes for a good reason; and that reason is because, in discovering the ECS, they’ve changed the way we look at the human body and medicine. Many used to believe that targeting one receptor using one highly purified drug was necessary, but the discovery of the ECS has changed their mind. Nowadays, much of the talk around developing safe pharmaceuticals concerns itself with the ECS and multi-modal treatments. In some cases, learning more about the medical properties of cannabis has made us better doctors.

Indeed, so significant is the discovery of cannabinoids and the endocannabinoid system, that it may help us answer one of life’s most fundamental questions: “How and why are we here?” This is because cannabinoids play a crucial role in the beginnings of life. To quote the Abstract from ‘The endocannabinoid-CB1 receptor system in pre- and postnatal life’:

“Recent research suggests that the endogenous cannabinoids (“endocannabinoids”) and their cannabinoid receptors have a major influence during pre- and postnatal development.

First, high levels of the endocannaboid anandamide and cannabinoid receptors are present in the preimplantation embryo and in the uterus, while a temporary reduction of anandamide levels is essential for embryonal implantation. In women accordingly, an inverse association has been reported between fatty acid amide hydrolase (the anandamide degrading enzyme) in human lymphocytes and miscarriage.

Second, CB1 receptors display a transient presence in white matter areas of the pre- and postnatal nervous system, suggesting a role for CB1 receptors in brain development.

Third, endocannabinoids have been detected in maternal milk and activation of CB1 receptors appears to be critical for milk sucking by newborn mice, apparently activating oral–motor musculature.

Fourth, anandamide has neuroprotectant properties in the developing postnatal brain. Finally, prenatal exposure to the active constituent of marihuana (Δ9-tetrahydrocannabinol) or to anandamide affects prefrontal cortical functions, memory and motor and addictive behaviors, suggesting a role for the endocannabinoid CB1 receptor system in the brain structures which control these functions.

Further observations suggest that children may be less prone to psychoactive side effects of Δ9-tetrahydrocannabinol or endocannabinoids than adults. The medical implications of these novel developments are far reaching and suggest a promising future for cannabinoids in pediatric medicine for conditions including “non-organic failure-to-thrive” and cystic fibrosis.”

Sprouting plant; new life; plant growing.
Picture from https://www.flickr.com/photos/mr_t_in_dc/5057059458; Picture by “Mr.TinDC”.

To break that down for you:

  • The body’s own version of THC, anandamide, is necessary for human life to happen in the first instance.
  • Cannabinoid receptors are necessary for brain development.
  • Endocannabinoids have been discovered in the maternal milk of mice, and there is no reason to believe that other mammals’ milk is not the same.
  • Anandamide protects the brains of newborns.
  • Prenatal exposure to THC or anandamide affects memory, motor and addictive behaviors, and prefrontal cortical functions.

Some theorize that children may actually be less prone to the psychoactive effects of THC! Though there is no definitive evidence behind this, the logic seems to be that, due to the high amounts of anandamide in children, THC may not affect them in the same way it affects adults! This is one more reason given as to why cannabinoids may be an excellent treatment method for children.

However, we are sceptical of this claim, as cannabinoids play a massive role in the development of the brain during childhood and teenage years, and introducing phytocannabinoids without medical supervision during such a sensitive period may cause potential health problems, in particular mental health. There is significant research suggesting that those aged under 25 are actually more sensitive to THC, as their brains are developing. As for CBD, as it is a cannabinoid that does not have any affinity for CB1 or CB2 receptors, it is unlikely to have the effects THC has. Still, we do not know for sure precisely what sort of effect has long-term. CBD still has a physiological effect, after all.

Those who need cannabinoids for a particular health condition, they are still a potentially valid treatment regardless of age. We must also ask ourselves, “Why don’t we treat many other drugs and medications the same way and see what effect they have on the brains of children?” After all, many children are prescribed much harsher drugs than THC when they suffer from serious conditions.

Chemical structure anandamide; anandamide; THC; anandamide THC; skeletal anandamide; endocannabinoid
Anandamide. Picture from: https://commons.wikimedia.org/wiki/File:Anandamide_skeletal.svg

 

 

 

 

 

 

 

 

 

 

 

Now, we don’t know about you, but this sort of thing gets us excited, and we’d be surprised if anyone doesn’t get as excited as we are about such research. Cannabinoids being one of the reasons why life exists? This is the sort of talk that belongs in stoner circles. Yet at least one of those circles must have the spirit of Carl Sagan and other prominent now sadly-passed scientists possessing them, as that talk may just well be true!

Now, not only do cannabinoids seem to have a massive role to play in the beginnings of life, but it may also perform an immensely important part in the continuation of it as well. Cannabinoids are intimately involved in homeostasis – the “checks and balances” that keep the body and its physiological processes in equilibrium. Anandamide is hugely important for maintaining immunological health in the gut. Learning about endocannabinoids and endocannabinoid has given us a greater understanding of immune regulation, and the advances made in cannabinoid pharmacology have given us a whole new range of therapeutic targets. In fact, the ECS has potentially given us an entirely new branch of therapies. The reason why cannabis may be useful for so many conditions is because an “out-of-tune” ECS is implicated in many disease states.

Infinity symbol; cannabis leaves; cannabis; hemp; infinity symbol made from marijuana leaves.
Picture from https://pixabay.com/en/marijuana-drugs-cannabis-drug-hemp-2766323/

That cannabinoids may make up the constituents of life is nothing short of an outstanding discovery. It is almost surprising that we have only just discovered it just over two-and-a-half decades ago. The ECS is so complex that we have barely just begun to scratch the surface on what it does and how we can modulate it. There is still lots more to be done, There is actually lots to be discussed here, and in some ways the way we treat the cannabis plant has asked a some questions that shake some of the philosophical underpinnings of medicine. “How do we ensure the cure isn’t as bad and dangerous as the disease we’re trying to treat?” “Why do we prescribe things that are much worse than cannabis, especially when sometimes the evidence is shaky at best?” “Are there ways we can treat a condition without the need for invasive surgery and/or harsh pharmaceutical drugs?” Who knows? One day, many of the medicines at your local pharmacist may be cannabinoid- and/or terpenoid- based!

Caffé Tlazo Launches Hemp Infused Menu

Adding some cannabinoids to your daily routine.

With so many of our natural food derived nutrients stripped away these days (whether from stripped soil or processed foods), we’re excited to announce that Caffé Tlazo in Algoma, WI is bringing them back with hemp infused teas, coffee and smoothies! With about 150 phytocannabinoids in the hemp plant, Native Roots Hemp products take advantage of far more than just CBD. It’s time you get ALL the benefits of full-spectrum, organically grown, Wisconsin hemp!

Jenelle Glime from Caffé Tlazo invites you to the healthy side of hemp with the newest addition of hemp-infused goodies to boost those CB1 and CB2 receptors. Keep your Endocannabinoid System in a healthy state of balance.

Why should you consider HEMP in your diet?

Because of your Endocannabinoid System, that’s why. This system acts like a message center that communicates with the CB1 and CB2 receptors found in the central nervous system (CB1 receptors) and peripheral organs like immune cells (CB2 receptors). The phyto-nutrients that come from the hemp plant are known as phyto-cannabinoids. These positively interact with the CB1 and CB2 receptors to bring you to a healthy state of balance.

NATIVE ROOTS HEMP. SUPPORTING WI FARMERS. ORGANICALLY GROWN HEMP.

Located in downtown De Pere, WI, with a licensed kitchen and private outdoor patio, Native Roots Hemp offers everything from Hemp/CBD and Delta 8 edibles and smokables to premium skincare products. They have what you’re looking for. And don’t forget your furry-friend! Native Roots Hemp also offers calming dog treats and pet oil. Native Roots Hemp prides itself on our one-on-one customer service, assisting you in choosing the right hemp/CBD product for you. Whether you’re beauty-obsessed, a fitness-enthusiast, just looking to destress or a senior, there is a hemp product for you.

Contact us at 920-487-8788, and learn more or order online with free delivery at nativerootshemp.com

Caffe Tlazo in Algoma Offers Native Roots Hemp
Caffe Tlazo is Comfy and CozyCaffe Tlazo is Comfy and Cozy

What’s the Scoop on Delta-8

How does Delta-8 make you feel?

According to Mercury News:  The effects of Delta8 THC and the traditional Delta-9 THC are fairly similar, but the potency of Delta8 is what sets it apart from its highly psychoactive counterpart. Delta8 can make you feel high, but it is thought to create a milder effect.

When combined with cannabinoids such as CBN (typically reportedly used for anxiety or sleep) the D8 has different effects.  Use it with CBD for a milder euphoric sensation.

And, while we don’t judge, millions of people choose to drink each week throughout America. Many of them suffer hangovers. And, while a high quality plant, such as a hemp plant is thought to lessen the after-effects of an alcohol-induced night out, users of Delta-8 THC report a euphoric feeling without the hangover.

How long will the effects of Delta-8 THC last?

Consumers report effects of Delta-8 can last anywhere from 3 – 8 hours.

Is Delta-8 Legal in Wisconsin?

According to Kush, a substance meeting the definition of “hemp” is legal for purposes of state and federal controlled substances laws regardless of its Delta 8-THC concentration.  This means that any hemp-derived Delta 8 THC that has less than .3% of Delta 9 THC is legal. 

The short answer is “yes.”

PetWants Launches Organic Canine Hemp Treats

Native Roots Hemp, Healthy Hempy Dog Treats

We know you love your fur baby. You’re probably the kind of pet parent who feeds them quality food right down to the treats you spoil them with. Earlier this year, Native Roots Hemp launched Barry’s Hemp Bones, a bite sized, oven baked dog biscuit in the shape of bone. This wholesome treat is gluten free, soy free, non-GMO and made with ingredients right from your cupboard such as organic peanut butter, gluten-free oats, and turmeric with a little added bonus; organically grown Wisconsin hemp.

Patrick Vieau, local owner of PetWants in Green Bay, set out on a mission this year to bring a new, USA Made, all natural ingredient, quality nutritious pet option to his line-up, Barry’s Hemp Bones. Patrick, pet parent of 2 dogs himself, states “we have to be more aware than ever what we are feeding our pets. The commercial dog food space is full of unnatural fillers and chemical preservatives, and these options are being recalled regularly.” Patrick, is very passionate in making sure his customers are getting only the most healthy and wholesome pet food options for their fur babies.

Reap the benefits of hemp for optimal pet health.

Why should you consider Barry’s Hemp Bones to support your pet’s everyday health? Pets, like humans, have an Endocannabinoid System. This system acts like a message center that communicates with the CB1 and CB2 receptors found in the central nervous system (CB1 receptors) and peripheral organs like immune cells (CB2 receptors). The phyto-nutrients that come from the hemp plant are known as phyto-cannabinoids. These positively interact with the CB1 and CB2 receptors to bring your pets health into a healthy optimal state of balance.

PetWants addition of Barry’s Hemp Bones means that this all natural treat compliments their selection of formula options which contain no corn, wheat, or soy. PetWants of Green Bay offers pet parents a convenient shop from home experience that directly ships to your home to ensure freshness. Shop with PetWants today and try Barry’s Hemp Bones.

NATIVE ROOTS HEMP APOTHECARY: QUALITY MADE WISCONSIN PRODCUTS FOR PETS AND PEOPLE

Located in downtown De Pere, with a private outdoor patio, Native Roots Hemp is a full-service hemp tea and coffee bar. From our edibles and smokables, to our body care products you will be sure to find something to meet your needs. Every product is crafted right here at our apothecary in De Pere. Native Roots Hemp prides itself on our one-on-one customer service, assisting you in choosing a hemp product you feel comfortable working with. We have product lines for the beauty-obsessed, for the man in your life, fitness-enthusiasts, and even for seniors. Contact us at 920-487-8788, and learn more or order online with free delivery at Native Roots Hemp.

What Are the Benefits of CBD?

More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?

By Dawn MacKeen

The CBD industry is flourishing, conservatively projected to hit $16 billion in the United States by 2025. Already, the plant extract is being added to cheeseburgers, toothpicks and breath sprays. More than 60 percent of CBD users have taken it for anxiety, according to a survey of 5,000 people, conducted by the Brightfield Group, a cannabis market research firm.Chronic pain, insomnia and depression follow behind. Kim Kardashian West, for example, turned to the product when “freaking out” over the birth of her fourth baby. The professional golfer Bubba Watson drifts off to sleep with it. And Martha Stewart’s French bulldog partakes, too.


Cannabidiol, or CBD,is the lesser-known child of the cannabis sativaplant; its more famous sibling, tetrahydrocannabinol, or THC, is the active ingredient in pot that catapults users’ “high.” With roots in Central Asia, the plant is believed to have been first used medicinally — or for rituals — around 750 B.C., though there are other estimates too.

Cannabidiol and THC are just two of the plant’s more than 100 cannabinoids. THC is psychoactive, and CBD may or may not be, which is a matter of debate. THC can increase anxiety; it is not clear what effect CBD is having, if any, in reducing it. THC can lead to addiction and cravings; CBD is being studied to help those in recovery.

Cannabis containing 0.3 percent or less of THC is hemp. Although last year’s Farm Bill legalized hemp under federal law, it also preserved the Food and Drug Administration’s oversight of products derived from cannabis.


CBD is advertised as providing relief for anxiety, depression and post-traumatic stress disorder. It is also marketed to promote sleep. Part of CBD’s popularity is that it purports to be “nonpsychoactive,” and that consumers can reap health benefits from the plant without the high (or the midnight pizza munchies).

Just as hemp seedlings are sprouting up across the United States, so is the marketing. From oils and nasal sprays to lollipops and suppositories, it seems no place is too sacred for CBD. “It’s the monster that has taken over the room,” Dr. Brad Ingram, an associate professor of pediatrics at the University of Mississippi Medical Center, said about all the wild uses for CBD now. He is leading a clinical trial into administering CBD to children and teenagers with drug-resistant epilepsy.

 

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