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You & Your Endocannabinoid System

Most people have heard an earful about the health benefits of CBD — its effects on stress-response, inflammation & immunity, pain, mood, and more — but the question of how and why CBD works opens a window onto a vast & complex system that science is still making sense of: the Endocannabinoid System (ECS).

The outlines of the ECS emerged during the 1960s and 70s, from research into the effects of cannabis on the human body.

Scientists were able to isolate numerous phytochemicals from the cannabis plant — phytocannabinoids (“phyto” means “plant”) — and by studying their effects revealed a web of receptors, enzymes, and biochemical pathways involved in manufacturing & using the body’s own form of cannabinoids: endocannabinoids (“endo“ means “originating within the body”).

Although research focused primarily on humans and other mammals, it turned out that we share these neurochemicals with most members of the animal kingdom, including mammals, birds, amphibians, fish, and even sea urchins. It’s now clear that the endocannabinoid system (ECS) evolved almost 600 million years ago.

Because the ECS arose so early, as animals evolved into more complex beings it became connected to many different physiological and neurological functions — which we’ll explore more in future articles. For now, here is a brief introduction to this vital system…

Stars of the Endocannabinoid System

  • Endocannabinoids (eCBs)
  • Cannabinoid receptors (CB receptors)
  • Enzymes that synthesize and break down eCBs

Endocannabinoids (eCBs)

Neurotransmitters like serotonin and dopamine are chemical messengers of the nervous system. Similarly, endocannabinoids (eCBs) are the messengers of the ECS, and are produced throughout your body.

The two key eCBs circulating in your body are anandamide and 2-arachidonoylglycerol. Just like the phytocannabinoids in cannabis, these neurotransmitters are built from lipids (fats or oils). (The lipid-based structure of cannabinoids is the reason why THC and CBD are fat-soluble…and why your typical cannabis or hemp extract is delivered in an oil base like coconut or butter.)

Anandamide was discovered in the 1990s and gets its name from the Sanskrit word ananda, or “bliss.” This molecule operates throughout the endocannabinoid system and is involved with appetite, memory, and pregnancy, to name just a few of its functions. It’s even been identified as the source of the “runner’s high” experienced during or after intense exercise.

CBD Eases Anxiety and Cravings of Heroin Addiction, New Study Finds

Every day, more than 130 people in the U.S. die after overdosing on opioids, according to a U.S. Department of Health and Human Services report from 2018. Addressing the opioid crisis with all the resources possible must be a top priority for government and scientists. The misuse of and addiction to opioids – including heroin, pain relievers, and synthetic opioids – is a snowballing, serious national crisis that affects public health.

A new study finds cannabidiol, the non-psychoactive ingredient in hemp and marijuana, could treat opioid addiction. 

The intense craving is what drives the drug use. If we can have the medications that can dampen that [craving], that can greatly reduce the chance of relapse and overdose risk,” noted Yasmin Hurd, the lead researcher on the study and director of the Addiction Institute of Mount Sinai. The study found that CBD immediately helped reduce cravings among heroin users, and it also noted the effects seemed to last seven days after the subjects were administered CBD, well beyond the time the drug is expected to be present in the body. The results of the study are published in the American Journal of Psychiatry.  

A team of New York-based scientists suggest CBD may have a role in helping to break the cycle of addiction.  Researchers at Mount Sinai Hospital in New York found a promising new use of CBD: a reduction of cravings and anxiety in individuals with a history of heroin abuse.  This is certainly welcome news as CBD may help break heroin drug addiction.

To address the critical need for new treatment options for the millions of people and families who are being devastated by this epidemic, we initiated a study to assess the potential of a nonintoxicating cannabinoid on craving and anxiety in heroin-addicted individuals,” explained lead study author Yasmin Hurd.

New CBD Flower in Wisconsin! Just $20 1/8th ounce

When quality flower is becoming more and more scarce, One Health WI
has reliable, 3rd party tested flower at over 20% cannabinoids.

What is CBD flower good for?  Here are just a few examples:

First, there are LOADS of recipes you can use and here are some
samples to get you started.  It may also save you money, depending on
your needed dose of CBD.

Our friends from Harvest, have these suggestions:

TWO ESSENTIAL TIPS FOR THE BEST CBD RECIPES
If you’re brand new to cooking or creating with cannabis, there are
two important factors to note when using flower in recipes, regardless
of whether you’re making food or body products.

Cannabinoids, both THC and CBD, need to be decarboxylated for maximum
benefit. Don’t let the term confuse you. It’s a simple process that
involves tossing your flower in the oven on low heat. Here are some
simple decarboxylation instructions.
Cannabidiol is fat soluble, which means it breaks down and is stored
in fat. This is why recipes often call for cannabis-infused oils or
butters, instead of flower.
7 CBD FLOWER RECIPES TO ADD TO YOUR RECIPE BOX
Here are a few ways you can incorporate CBD flower into your food,
supplements and personal care routines.

CBD COCONUT OIL
Some people believe that coconut oil is the best way to gain maximum
benefits from CBD. Because cannabidiol is fat soluble and coconut oil
is 80% saturated fat, coconut oil a great binding agent for
cannabinoids that supports efficient absorption in the blood stream
and across the rest of the body.

There are seemingly endless ways to use coconut oil. You can cook with
it, bake with it, add it to your coffee or rub it on your skin.
Whether you’re consuming it or applying it topically, by using
CBD-infused coconut oil, you get the benefits of both powerful
ingredients.

If you’ve never made CBD coconut oil, here’s our recipe.

CBD HONEY
There’s nothing like a little honey to soothe your body and soul. It
has a host of known health benefits. And few things go better with
honey than a little cannabis.

CBD-infused honey is just as simple to make as CBD oil. Plus, it’s
versatile enough to include in a variety of dishes. Break out the
baking pans, spread it on some toast or get out the baking pans.

CBD TEA
Speaking of tea… Cannabis flower makes a natural addition to homemade teas.

Tea is a lovely way to combine CBD with other herbs in order to get
specific effects. Consider blending your CBD flower with:

Peppermint CBD for upset stomachs
Chamomile CBD to reduce anxiety and promote a good night’s sleep
Black or green tea leaves mixed with CBD for a caffeine boost or to
knock out a headache
For more subtle effects, you can skip decarboxylation, dry out your
flower and toss it in a tea ball. If you want stronger results,
remember to pop your flower in the oven before making your tea blend.
And consider adding some coconut oil or heavy creamer to your tea to
increase cannabinoid absorption.

CBD KOMBUCHA
Kombucha has been consumed for more than 2,000 years to improve
digestion, along with a host of other benefits. Given cannabis’s
benefits for nausea, digestive issues and overall gut health, coupling
kombucha with CBD might just be a match made in heaven.

CBD-infused kombucha and other beverages are starting to pop up in
breweries across the country. But you don’t need to be near a trendy
pub to enjoy some CBD kombucha. You really can make it at home. Here’s
a simple recipe for cannabis kombucha. This one uses store-bought
kombucha, but if you’re feeling up for a challenge, you can certainly
make yours from scratch.

CBD SEASONING
If you’re just getting started using cannabis in the kitchen, one of
the easiest ways to include into recipes is to add it as a seasoning.
Just dry a batch of flower out in the oven and crush it up. CBD
seasoning makes a great addition a multitude of dishes, especially
those with an Italian flare.

If you want your CBD recipes to be nutritious and delicious, Here’s a
phenomenal guide to help you determine which recipes and herbs to pair
your CBD seasoning with.

CBD CAPSULES
Not everyone is a fan of the way cannabis changes the flavor of their
food. If you’re one of these people, there is an alternative way to
ingest your cannabinoids. Consider making CBD capsules.

Canna caps can especially be the right option for people who are
already taking vitamins or other supplements. This Leafly article has
a great recipe, plus tips for controlling dosage.

CBD BATH BOMBS
Topical products are great remedies for those using CBD for pain
relief. Bath bombs and bath salts can be a lovely way to incorporate
CBD into your body care routine. While you can find some of these
products at your local Harvest dispensary, they’re fun and easy to
make at home.

You can just toss your dried flower into your bath, but we recommend
making a CBD-infused coconut oil and adding the oil to a bath bombs
recipe. The coconut oil will enhance the effects of the CBD so you get
more health benefits from your medicine.

Beyond the basic CBD bath bomb recipe, consider using essential oils,
food coloring and shaping molds to customize your bath bombs.

GET STARTED MAKING YOUR CBD RECIPES
Although smoking cannabis flower has culturally been the most common
method of consumption, that doesn’t mean it’s the best. There are no
shortage of ways you can use CBD and other cannabinoids to enhance
your physical health.

So, pick up a bag of cannabis flower, break out your recipe cards and
start experimenting today. We’d love to hear how your CBD recipes turn
out!

Research Shows CBD Benefits 50+ Conditions

Over the last few years, Cannabidiol (CBD) has exploded into the world of health and wellness.

With dozens of natural benefits, CBD has been used to ease conditions such as anxietyepilepsyneurodegenerative diseases and more.

For the last century, researchers have assessed CBD as a treatment for numerous conditions. More than 50, in fact.

What these studies show is profound.

If you are looking for research on CBD benefits for a certain condition, you will find it here.

From mental health to MS, we have gathered a collection of more than 250 resources, organized by condition.

Check out the collection below and feel free to share your thoughts in the comments below.

Studies Reveal CBD Benefits More Than 50 Conditions

Research on CBD Benefits by Condition - CBD Origin

Browse Medical Research Based on Condition

#CONDITIONMEDICAL RESEARCH
5CBD FOR ACNECannabidiol as a Treatment for Acne?
CBD FOR ACNECannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
CBD FOR ACNEThe endocannabinoid system of the skin in health and disease: Novel perspectives and therapeutic opportunities
CBD FOR ACNEEndocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling
CBD FOR ACNEEndocannabinoid signaling and epidermal differentiation
6CBD FOR ADD / ADHDSearching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders
CBD FOR ADD / ADHDCannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats
CBD FOR ADD / ADHDSubtypes of Attention Deficit — Hyperactivity Disorder (ADHD) and cannabis use
CBD FOR ADD / ADHDChildhood and current ADHD symptom dimensions are associated with more severe cannabis outcomes in college students
CBD FOR ADD / ADHDOral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: A case report
CBD FOR ADD / ADHDFitness to drive in spite (because) of THC
10CBD FOR ADDICTIONCannabidiol reduces cigarette consumption in tobacco smokers
CBD FOR ADDICTIONCannabidiol inhibits the reward-facilitating effect of morphine
CBD FOR ADDICTIONCannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances
CBD FOR ADDICTIONDifferential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats
CBD FOR ADDICTIONImpact of Cannabis Use during Stabilization on Methadone Maintenance Treatment
CBD FOR ADDICTIONMedical cannabis laws and opioid analgesic overdose mortality in the United States, 1999-2010
CBD FOR ADDICTIONDysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents
CBD FOR ADDICTIONComparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity
CBD FOR ADDICTIONTransdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder
CBD FOR ADDICTIONCannabidiol for the treatment of cannabis withdrawal syndrome
4CBD FOR ALSCannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials
CBD FOR ALSALS: delayed disease progression in mice by treatment with a cannabinoid
CBD FOR ALSThe (Endo)Cannabinoid System in Multiple Sclerosis and ALS
CBD FOR ALSSurvey of cannabis use in patients with ALS
16CBD FOR ALZHEIMERSThe therapeutic potential of the endocannabinoid system for Alzheimer’s disease
CBD FOR ALZHEIMERSEndocannabinoid signalling in Alzheimer’s disease
CBD FOR ALZHEIMERSA molecular link between the active component of marijuana and Alzheimer’s disease pathology
CBD FOR ALZHEIMERSNeuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
CBD FOR ALZHEIMERSThe Potential Therapeutic Effects of THC on Alzheimer’s Disease
CBD FOR ALZHEIMERSThe Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease
CBD FOR ALZHEIMERSCannabinoids for the treatment of dementia
CBD FOR ALZHEIMERSCannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression
CBD FOR ALZHEIMERSCannabidiol: A promising drug for neurodegenerative disorders?
CBD FOR ALZHEIMERSCannabinoid receptor 1 deficiency in a mouse model of Alzheimer’s disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
CBD FOR ALZHEIMERSThe role of the endocannabinoid system in Alzheimer’s disease: facts and hypotheses
CBD FOR ALZHEIMERSThe role of phytochemicals in the treatment and prevention of dementia
CBD FOR ALZHEIMERSCannabinoids for the treatment of dementia
CBD FOR ALZHEIMERSCannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement
CBD FOR ALZHEIMERSCannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
CBD FOR ALZHEIMERSCan Marijuana Prevent Alzheimer’s?

Using CBD (Cannabidiol) to Treat the Symptoms of Alzheimer’s & Other Dementias

What is CBD?

CBD (aka Cannabidiol) is a compound derived from the Cannabis plant that has positive medicinal effects but does not make people feel “high,” or anxious. CBD, in various forms, is legal in 47 US States.

CBD should not be confused with Marijuana or the THC (Tetrahydrocannabinol) compound which is known for generating a “high” with users. CBD is derived from Cannabis plants, similar to how caffeine is derived from the coffee bean, or aspirin from the bark of a Willow tree. CBD oil is the most common form of administration of the compound with the oil contained in a gel cap or dropper bottle.

CBD Health Benefits for Dementia

The dementia-related conditions that can be helped by CBD include: Alzheimer’s disease, Vascular Dementia, Dementia with Lewy bodies (DLB), Parkinson’s disease, Frontotemporal dementia and Huntington’s disease.

According to researchers at California’s Salk Institute, their 2017 study has found evidence that cannabinoids such as CBD could help remove dementia from brain cells. While the US Food and Drug Administration has yet to approve a CBD drug for the purposes of treating dementia, it has approved a CBD-based drug for treating epilepsy.

There are three ways CBD can work to improve health outcomes for persons with dementia: by reducing inflammation, by reducing oxygen buildup, and by working as a brain stimulant and neuroprotectant. From a user’s perspective, CBD may reduce stress and anxiety in the individual with dementia as well as reduce the decline of memory and other brain functions.

It should be noted that much controversy surrounds CBD and the claims companies have made as to its positive effects.

Alzheimer’s Disease

The topic of CBD health benefits continues to grow with new CBD and Alzheimer’s research. In recent studies, CBD has been shown to reduce or remove the impact of inflammation, oxygen buildup and brain cell decline.

Inflammation has been shown to increase the negative impact of Alzheimer’s disease. The inflammatory response happens when the brain’s immune cells fail to clear disorienting blockages. The inflammation that is a core cause of Alzheimer’s symptoms can often be reduced by using CBD oil.

Oxygen is released as a reactive, stress-induced component of Alzheimer’s disease. When inflammation happens in the brain, oxygen is released as a result. The greater the inflammation, the greater the negative impact. Important brain functions such as memory are decreased as more oxygen is released in the brain’s cells. Memory loss and other brain deterioration indirectly leads to increased oxygen in the brain. CBD is an antioxidant, which helps reduce the problems associated with oxygen stress. Brain functions negatively impacted by oxygen stress can be improved by using CBD.

Alzheimer’s patients’ brain cells often show a path of rapid decline and destruction. The potential of stimulating brain tissue was recently discovered as a potential benefit of CBD. In clinical trials, CBD has shown the ability to reverse and even prevent the development of Alzheimer’s negative impact. A 2011 study by Australian researchers Tim Karl and Carl Group found that CBD promotes the growth and development of brain cells, which were shown to reduce the decline of memory and other brain functions.

Vascular Dementia

Vascular dementia is a general term describing problems with reasoning, planning, judgment, memory and other thought processes caused by brain damage from impaired blood flow to one’s brain. To effectively treat vascular dementia, a 2016 study by the US National Institute of Health (NIH) found that activating CB2 (cannabinoid) receptors in the brain helped recover better blood flow to the brain. Activating the CB2 receptors with CBD has increased brain cell activity and helped reduce brain cell damage commonly associated with vascular dementia.

Dementia with Lewy Bodies

Lewy body dementia (LBD) is a disease associated with abnormal deposits of a protein called alpha-synuclein in the brain. These deposits, called Lewy bodies, affect chemicals in the brain whose changes, in turn, can lead to problems with thinking, sleeping, movement, behavior, and mood. Unlike most pain, anxiety or behavior management drugs, CBD does not block acetylcholine, the main chemical that LBD attacks. Research has shown that CBD can be an effective anti-inflammatory agent, reduce motor symptoms (tremor, rigidity, bradykinesia) and maintain circadian (sleep) rhythms.

Parkinson’s Disease

Parkinson’s is a chronic progressive disease of the nervous system chiefly affecting middle-aged and elderly people. Parkinson’s is linked to decreased dopamine production and marked by tremor, muscular rigidity, and slow, imprecise movement. Digestive imbalance may also play a role in the progression of Parkinson’s and the severity of symptoms. Cannabinoids such as CBD have shown to contain effective brain protectors, antioxidants and anti-inflammatory properties which can be beneficial for managing Parkinson’s disease. Read more about Parkinson’s and CBD.

Frontotemporal Dementia / Pick’s Disease

Frontotemporal dementia (FTD) or frontotemporal degenerations refers to a group of disorders caused by progressive nerve cell loss in the brain’s frontal lobes (the areas behind one’s forehead) or its temporal lobes (the regions behind one’s ears) that leads to symptoms of depression and psychosis. Unlike most anti-psychotic drugs, CBD does not lead to an increased risk of death. Research has shown that CBD can be an effective anti-inflammatory agent, reduce anxiety, reduce motor symptoms (tremor, rigidity, bradykinesia) and maintain circadian (sleep) rhythms.

Green Bay CBD Company Expands in Algoma, WI

Algoma, WI – Mike Swille from Green Bay, WI and Stacy Deprey-Purper, an Algoma, WI native, have teamed up to launch One Health WI, a unique offering which aims to help people from all socio-economic backgrounds lead healthier lives with an affordable, synthetic drug-alternative, CBD-A (Cannabinoid Oil).

In a 2016 study conducted by the FDA, only 2 in 24 companies contained what the labels on the CBD products stated. “This is a nation-wide educational epidemic for both doctors and consumers, alike. Since CBD is becoming mainstream and thanks to the 2014 Farm Bill, Hemp-derived CBD is legal in all 50 states. The confusing part for many is that folks have a difficult time understanding CBD derived from Hemp and CBD that comes from Marijuana. Only Hemp CBD is legal in all 50 states.”

This confusion is part of One Health WI’s mission according to Deprey-Purper. “We have a desire to help our fellow Wisconsinites understand how to choose a legal and quality CBD oil. This starts with education and awareness. We’re hosting free classes which provide good information to help people navigate the waters.”

art of that education is helping people understand what a quality oil looks like and to ask specific questions about how the oil was processed and produced to ensure you’re not wasting your money or ingesting any chemicals. The new store location will host local classes to address the misinformation.

One Health WI sources oils in the top 5% for quality. Deprey-Purper stated the company aims to make quality drug alternatives available for any budget. “It is our hope that people using opioids or over-the-counter medications for pain, inflammation, anxiety or other ailments will look to an alternative like CBD before any side effects or long-term damage is done using synthetic medications.” According to the CDC doctor-prescribed medications like oxycodone, hydrocodone, fentanyl and codeine were responsible for more than 70,237 deaths in 2017, which was up by nearly 10% in previous years.

“We’re especially seeing a significant rise in CBD use in consumers over the age of 65. They’re recognizing less side effects than their opioid prescriptions such as balance issues, constipation, energy levels and more, Deprey-Purper stated.

One Health currently bottles and produces products locally such as oils, balms and facial and bath items with pharmaceutical grade CBD. The company is testing local Kewaunee and Door County Area soils with the goal to move the entire farming production, locally. “We need to ensure that the Wisconsin soil is going to be able to produce the same quality and nutrient-rich CBD we’re currently sourcing from our current farms” Swille stated.

One Health WI launched in early fall of 2018 as a wholesale, quality CBD company with resellers in Florida, Arizona, Michigan and Wisconsin.

The grand opening celebration and Ribbon Cutting with the Algoma Chamber of Commerce will take place May 17, 2019 from 12-1 pm. The shop is slated for a May 8th opening at 219 Steele Street, Algoma, WI.
For more information contact Stacy Deprey-Purper at Farm2Pharmacy.com or 920-372-2420.

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